Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or
NEGATIVE. The breakpoint for sensillum SST is 43 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent
certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Linear Discriminant Analysis (LDA) algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. A number of 8 QuBiLS-MIDAS descriptors are in the classification model,
namely:
Q2_F_AB_nCi_2_M3_NS1_T_LGP[1]_v_MID
MX_B_AB_nCi_2_M14_SS2_n_T_LGP[1]_r-e_MID
AC[1]_S_F_AB_nCi_2_M10_MP0_T_LGP[2]_c_MID
S_B_AB_nCi_2_M5_NS4_T_LGL[2-3]_a-h_MID
ES_K_B_AB_nCi_2_M3_NS0_o_T_LGP[2]_v-h_MID
N2_F_AB_nCi_2_M12_NS5_T_LGL[1-2]_a_MID
N3_Q_AB_nCi_2_M11_MP4_o_T_LGST(PI)[0.0-1.0]_e_MID
K_B_AB_nCi_2_M3_NS7_T_LGL[2-3]_r-v_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.786, ROC Area = 0.959, PRC Area = 0.959, TP Rate = 0.90, FP Rate = 0.122, Q (%) = 90, and Precision
= 0.90.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016