Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE. The breakpoint for sensillum SBT-II-A is 20.4 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.

The training was performed with Bagging algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using John Platt's sequential minimal optimization algorithm for training a support vector classifier (SMO- with Pearson Universal Kernel (PUK)). A number of 7 QuBiLS-MIDAS descriptors are in the classification model, namely:

AC[5]_I50_TrB_AB_nCi_3_M20(M16)_SS2_T_KA_e-v_MID
ES_I50_TrC_AB_nCi_3_M28_SS1_T_KA_v_MID
AC[3]_K_Tr_AB_nCi_3_M21(M8)_SS1_T_KA_m-a-c_MID
S_Tr_AB_nCi_3_M25(M2)_NS6_T_KA_a-e-v_MID
VC_TrQB_AB_nCi_3_M26(M10)_SS7_T_LGBA[0.0-0.314]_m-r_MID
MX_TrC_AB_nCi_3_M22(M3)_SS4_T_LGA[0.0-1.0]_h_MID
GV[3]_K_TrB_AB_nCi_3_M25(M1)_SS7_T_KA_p-s_MID

Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016

Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.645, ROC Area = 0.812, PRC Area = 0.784, TP Rate = 0.82, FP Rate = 0.198, Q (%) = 82, and Precision = 0.831.

Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177. DOI: 10.1016/j.jinsphys.2013.08.016