Description:
Regression ensemble of sensillum SST with 4 individual models (I11, I16, I21 and I22) used for prediction of spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus repellents.

The training was performed with M5P algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. Models I11, I16, I21 and I22 were developed by using 10, 7, 9, and 7 QuBiLS-MIDAS descriptors, respectively, namely:

MN_Q_AB_nCi_2_M10_SS2_T_LGP[2]_v_MID
TS[2]_I50_F_AB_nCi_2_M15_MP1_T_KA_alk_MID
K_F_AB_nCi_2_M10_SS7_o_T_LGP[2]_a_MID
S_F_AB_nCi_2_M14_NS2_n_T_LGL[2-3]_v_MID
AC[1]_S_F_AB_nCi_2_M10_MP0_T_LGP[2]_c_MID
ES_K_B_AB_nCi_2_M3_NS0_o_T_LGP[2]_v-h_MID
N2_F_AB_nCi_2_M12_NS5_T_LGL[1-2]_a_MID
ES_S_B_AB_nCi_2_M3_NS6_n_T_LGP[2]_a-psa_MID
ES_I50_F_AB_nCi_2_M1_SS0_T_LGL[2-3]_e_MID
K_B_AB_nCi_2_M3_NS7_T_LGL[2-3]_r-v_MID
RA_TrF_AB_nCi_3_M21(M13)_MP6_T_LG3L[2-3]_LGL[2-3]_p_MID
ES_I50_Q_AB_nCi_2_M1_SS1_n_T_LGP[1]_e_MID
ES_S_B_AB_nCi_2_M3_SS6_T_LGP[2]_a-e_MID
AC[4]_S_B_AB_nCi_2_M5_NS6_T_LGL[1-2]_m-s_MID
TS[1]_K_Tr_AB_nCi_3_M28_SS3_T_KA_a-v-p_MID
TS[4]_K_TrC_AB_nCi_3_M27_NS0_T_KA_a_MID
VC_TrC_AB_nCi_3_M20(M16)_SS3_T_LGTP[12-13]_p_MID
I50_TrF_AB_nCi_3_M26(M5)_SS2_T_LGBA[0.314-0.628]_p_MID
SD_TrB_AB_nCi_3_M20(M13)_MP1_T_LGTP[12-13]_r-p_MID
I50_TrB_AB_nCi_3_M26(M11)_MP3_T_LGBA[0.0-0.314]_r-p_MID
MX_TrB_AB_nCi_3_M26(M16)_MP1_T_LGBA[0.0-0.314]_m-r_MID
N1_TrC_AB_nCi_3_M20(M10)_SS4_T_LGTP[9-10]_h_MID
MX_B_AB_nCi_2_M14_SS3_n_T_LGP[1]_h-s_MID
S_B_AB_nCi_2_M11_SS6_o_T_LGL[1-2]_a-v_MID
ES_S_B_AB_nCi_2_M8_NS3_o_T_LGP[2]_v-h_MID
K_B_AB_nCi_2_M12_SS3_o_T_LGL[1-2]_r-m_MID

Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016

Performance:
For a 10-fold cross-validation, the statistical parameters (performance without applicability domain) are R = 0.9825, MAE = 1.1998, RMSE = 2.7693, RAE = 10.8916 %, and RRSE = 18.1595 %.

Classification Breakpoint:
The breakpoint for sensillum SST is 43 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum. Lower values represent certain actions occurring, however, they are not enough to activate the sensillum response.

Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177. DOI: 10.1016/j.jinsphys.2013.08.016