Description:
Regression model of sensillum SBT-I-A with 6 QuBiLS-MIDAS descriptors used for prediction of spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus repellents.

The training was performed with Vote algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using a combination of the maximum probability (agglomeration rule) of Gaussian Processes (with Pearson Universal Kernel (PUK)), Linear Regression, and M5P tree. The 6 QuBiLS-MIDAS descriptors are namely:

RA_TrF_AB_nCi_3_M28_MP1_T_LGBA[1.570-1.884]_p_MID
S_Tr_AB_nCi_3_M22(M15)_NS2_T_KA_a-e-v_MID
AC[3]_S_B_AB_nCi_2_M8_SS1_o_T_LGP[2]_v-s_MID
AC[3]_S_Q_AB_nCi_2_M3_SS5_o_T_LGL[1-2]_p_MID
I50_TrB_AB_nCi_3_M22(M16)_MP1_T_KA_r-p_MID
ES_S_B_AB_nCi_2_M3_SS2_T_LGL[1-2]_v-s_MID

Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016

Performance:
For a 10-fold cross-validation, the statistical parameters (performance without applicability domain) are R = 0. 7558, MAE = 7.9417, RMSE = 10.4025, RAE = 60.286 %, and RRSE = 67.2734 %.

Classification Breakpoint:
The breakpoint for sensillum SBT-I-A is 13.2 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum, while lower values represent certain actions occurring, however, these are not enough to activate the sensillum response.

Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177. DOI: 10.1016/j.jinsphys.2013.08.016