Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SST is 43 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent certain
actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Stacking algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using as Bayes Net as metaclassifier and the classifiers are: Bayes Net, Fisher’s Linear Discriminant
Analysis (FLDA), Logistic, Stochastic Gradient Descent (SGD), and Random Forest. A number of 7 QuBiLS-MIDAS descriptors are in the classification model, namely:
Q2_F_AB_nCi_2_M3_NS1_T_LGP[1]_v_MID
MX_B_AB_nCi_2_M14_SS2_n_T_LGP[1]_r-e_MID
AC[1]_S_F_AB_nCi_2_M10_MP0_T_LGP[2]_c_MID
S_B_AB_nCi_2_M5_NS4_T_LGL[2-3]_a-h_MID
N2_F_AB_nCi_2_M12_NS5_T_LGL[1-2]_a_MID
AC[1]_S_F_AB_nCi_2_M8_SS7_o_T_LGL[5-6]_c_MID
K_B_AB_nCi_2_M3_NS7_T_LGL[2-3]_r-v_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.80, ROC Area = 0.941, PRC Area = 0.919, TP Rate = 0.90, FP Rate = 0.082, Q (%) = 90, and Precision
= 0.909.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016