Description:
Regression ensemble of sensillum SBT-II-A with 3 individual models (I2, I21, and I24) used for prediction of spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus repellents.

The training was performed with the Linear Regression algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. Models I2, I21, and I24 were developed by using 10, 6, and 4 QuBiLS-MIDAS descriptors, respectively, namely:

MX_TrB_AB_nCi_3_M19(M1)_SS7_T_LG3P[1]_LGP[1]_r-p_MID
AC[4]_S_F_AB_nCi_2_M11_SS2_T_LGP[2]_c_MID
SD_TrB_AB_nCi_3_M19(M11)_MP4_T_LGTP[12-13]_r-p_MID
GV[1]_K_Tr_AB_nCi_3_M25(M15)_NS1_T_KA_m-a-c_MID
VC_TrQB_AB_nCi_3_M26(M10)_SS7_T_LGBA[0.0-0.314]_m-r_MID
AC[3]_K_Tr_AB_nCi_3_M21(M8)_SS1_T_KA_m-a-c_MID
S_Tr_AB_nCi_3_M25(M13)_NS7_T_LGA[1.0-2.0]_a-e-v_MID
S_Tr_AB_nCi_3_M25(M2)_NS6_T_KA_a-e-v_MID
TS[1]_K_TrC_AB_nCi_3_M27_SS1_T_KA_p_MID
AC[5]_I50_TrB_AB_nCi_3_M20(M16)_SS2_T_KA_e-v_MID
AC[1]_S_F_AB_nCi_2_M15_SS1_T_LGP[2]_c_MID
K_B_AB_nCi_2_M13_NS1_o_T_LGL[1-2]_h-s_MID
Q3_B_AB_nCi_2_M5_NS6_T_LGL[1-2]_p-h_MID
MN_Q_AB_nCi_2_M14_NS1_T_LGL[1-2]_h_MID
AC[5]_S_Q_AB_nCi_2_M12_MP0_T_LGL[1-2]_h_MID
RA_TrF_AB_nCi_3_M21(M11)_MP7_T_KA_p_MID
GV[3]_K_TrB_AB_nCi_3_M25(M15)_SS3_T_LG3L[2-3]_LGL[2-3]_r-s_MID

Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016

Performance:
For a 10-fold cross-validation, the statistical parameters (performance without applicability domain) are R = 0.9628, MAE = 1.8602, RMSE = 3.4628, RAE = 21.3198 %, and RRSE = 26.5957 %.

Classification Breakpoint:
The breakpoint for sensillum SBT-II-A is 20.4 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum. Lower values represent certain actions occurring, however, they are not enough to activate the sensillum response.

Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177. DOI: 10.1016/j.jinsphys.2013.08.016