Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SBT-I-B is 16.3 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent
certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Fisher's Linear Discriminant function algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. A number of 9 QuBiLS-MIDAS descriptors are in the classification model,
namely:
K_B_AB_nCi_2_M11_SS7_o_T_LGL[1-2]_a-p_MID
MX_Q_AB_nCi_2_M8_SS3_T_LGP[2]_v_MID
AC[2]_S_Q_AB_nCi_2_M1_SS0_o_T_LGL[1-2]_s_MID
GV[5]_AM_TrQB_AB_nCi_3_M20(M16)_SS3_T_LG3L[1-2]_LGL[1-2]_p-h_MID
AC[2]_K_B_AB_nCi_2_M8_SS2_n_T_LGP[2]_e-p_MID
HM_Q_AB_nCi_2_M12_SS4_T_LGP[5]_p_MID
GV[3]_K_TrB_AB_nCi_3_M22(M1)_SS7_T_KA_p-s_MID
AC[5]_S_Q_AB_nCi_2_M10_MP4_T_LGL[2-3]_c_MID
AC[1]_S_B_AB_nCi_2_M8_SS3_n_T_LGP[2]_e-p_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.612, ROC Area = 0.839, PRC Area = 0.846, TP Rate = 0.806, FP Rate = 0.194, Q (%) = 80.597, and
Precision = 0.806.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016