Description:
Regression ensemble of sensillum SST-C with 2 individual models (I4 and I14) used for prediction of spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to
Cx. quinquefasciatus repellents.
The training was performed with Vote algorithm as default in Weka 3.9.4 with a 10-fold cross-validation using a combination of the maximum probability (agglomeration rule) of Linear Regression, SMOreg (with
Pearson Universal Kernel (PUK)), and M5P tree. Models I4 and I14 were developed by using 6 and 3 QuBiLS-MIDAS descriptors, respectively, namely:
AC[5]_S_Q_AB_nCi_2_M12_MP0_T_LGL[1-2]_a_MID
GOWAWA[0.5;1;S-OWA;0.8;0.2;1;ES2-OWA;0.9]_Q_AB_nCi_2_M2_MP2_A_LGP[1;2;5;9]_hx_MID
AC[6]_RA_B_AB_nCi_2_M8_MP5_T_KA_a-r_MID
S_B_AB_nCi_2_M10_SS7_T_LGL[5-6]_c-h_MID
ES_SD_B_AB_nCi_2_M12_MP2_C_LGL[5-6]_e-p_MID
AC[2]_S_F_AB_nCi_2_M16_MP1_T_LGP[1]_c_MID
CHOQUET[D;0.5;AO2;0.6]_Q_AB_nCi_2_M14_SS4_T_LGL[2-5]_e_MID
AC[4]_S_Q_AB_nCi_2_M1_SS7_o_T_LGL[1-2]_a_MID
ES_SD_F_AB_nCi_2_M1_SS1_T_LGP[5]_a_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (performance without applicability domain) are R = 0.9953, MAE = 0.7427, RMSE = 1.6894, RAE = 5.335 %, and RRSE = 9.592 %.
Classification Breakpoint:
The breakpoint for sensillum SST-C is 13.5 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum. Lower values represent certain actions occurring, however,
they are not enough to activate the sensillum response.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016