Description:
Classification model developed to predict the spike amplitude of the extracellularly record of ORN response potentials of the antennal trichoid sensilla to Cx. quinquefasciatus in two classes: POSITIVE or NEGATIVE.
The breakpoint for sensillum SBT-II-B is 32.8 spikes/s. Values greater than or equal to the breakpoint will elicit a response in this specific sensillum and are represented as POSITIVE. Lower values represent
certain actions occurring, however, these are not enough to activate the sensillum response, these are classified as NEGATIVE.
The training was performed with Logistic function algorithm as default in Weka 3.9.4 with a 10-fold cross-validation. A number of 7 QuBiLS-MIDAS descriptors are in the classification model, namely:
N1_TrB_AB_nCi_3_M26(M1)_MP4_T_LGA[1.0-2.0]_r-p_MID
I50_TrF_AB_nCi_3_M19(M13)_SS3_T_LG3P[1]_LGP[1]_p_MID
I50_TrF_AB_nCi_3_M21(M1)_SS7_T_KA_p_MID
I50_TrC_AB_nCi_3_M19(M8)_NS3_T_LG3P[1]_LGP[1]_h_MID
I50_TrC_AB_nCi_3_M25(M5)_NS2_T_LGBA[0.314-0.628]_h_MID
MX_Tr_AB_nCi_3_M19(M5)_MP4_T_LG3L[6-7]_LGL[6-7]_a-e-v_MID
I50_TrF_AB_nCi_3_M22(M8)_MP1_T_KA_p_MID
Training set:
50 compounds extracted from the Liu, et al., 2013 original experimental research constitute the training set 10.1016/j.jinsphys.2013.08.016
Performance:
For a 10-fold cross-validation, the statistical parameters (Performance without applicability domain) are MCC = 0.883, ROC Area = 0.991, PRC Area = 0.991, TP Rate = 0.96, FP Rate = 0.077, Q (%) = 96, and Precision
= 0.96.
Reference:
Liu et al. Olfactory responses of the antennal trichoid sensilla to chemical repellents in the mosquito, Culex quinquefasciatus. 2013, 59(11), 1169-1177.
DOI: 10.1016/j.jinsphys.2013.08.016